Here is a summation of everything that I am thinking right now:
The show wants to bring down Sonny over the next two years. Jason and Carly will oppose Sonny and work with law enforcement to bring Sonny down. After the fall of Sonny the show will move away from mob stories and focus on the hospital. Sonny will kill Dex, and that will inspire Jason, Carly, and Josslyn to more actively oppose Sonny. Jason will associate with the Quartermaines again. Michael will rename himself and his kids Quartermaine.
The show will phase out the Chase family. Harrison will marry Brook Lynn and join the Quartermaine clan. Gregory will die shortly afterward. I think that Gregory will dance with Tracy at the reception and then drop dead. After his father's death, Finn will find an excuse to leave town.
Ava will follow Sonny down a dark path, which will eventually lead to her exit from the show. Ava is another mob character the show needs to eliminate in order to go in a different direction.
Laura and Kevin will adopt Ace and call him Ace Collins. Ace will be part of the Hardy-Webber clan.
Alexis will become a lawyer again. She will then become Heather's lawyer and will get Heather out of prison.
Heather will live with Laura and help Laura raise Ace. Heather and Laura will become like sisters. Heather and Cyrus will fall in love.
Trina will meet a new guy at the wedding. They will date and have a healthier relationship than the one she had with Spencer.
Cam will be recast and return to the show in the summer. After the death of Dex, Josslyn will get back together with Cam.
Pikeman will be revealed as the new owners of Wyndemere. Pikeman will use the island and the castle as a headquarters. Valentin is the leader of Pikeman and the person who killed Austin. Valentin and Pikeman will be defeated by the end of the year and then Valentin will be off the show.
Lulu will wake up in the second half of this year. Her awakening will be followed by Lucky's return to town. Lucky will seek to get back together with Elizabeth.
Nikolas will remain in prison for the rest of this year, and until the writers want to use him again.
Spencer will remain missing until next year, when the role will be recast. He will find Trina in a committed relationship with a new guy, and a triangle will commence.
Esme will also eventually return in a year or two, but as a villain.
Mac will return and then Cody will reveal to him that he is his son.
Cody and Sasha will fall in love and eventually leave town together.
Molly will be killed either by her uncle or by his enemies.
Kristina and Blaze will get married and keep the baby for themselves. TJ won't be able to win custody of the baby in court.
Robert will retire. Holly will return to town one last time. Robert and Holly will then ride off into the sunset together.